The cell handling process is critical in fields such as biotechnology, pharmaceuticals, and immunology, where precise control over cellular conditions is necessary. One area where proper cell handling is particularly important is in the study and treatment of sepsis, a life-threatening condition caused by the body’s overwhelming response to infection.
INTELLISEP®
Cytovale
The Cytovale IntelliSep® is an advanced diagnostic tool designed to rapidly and accurately identify sepsis within minutes, utilizing innovative cell biophysical properties to distinguish between infected and non-infected patients. This groundbreaking technology enhances clinical decision-making and improves patient outcomes by providing critical information swiftly and effectively.
Challenge(s)
The Customer's Brief
Cytovale approached STRATEC with a set of specific objectives in the beginning of the project. Most importantly building a microfluidic platform being able to monitor cells and its deformation within the channel by a high speed camera setup. STRATEC to take care about the reliable and precise manufacturing of the microfluidic core component and to deliver high quality microfluidic devices with a bonding precision of +- 200 nm.
OUR SOLUTION
STRATEC Consumables brought several advanced solutions to the Cytovale IntelliSep project, enhancing its development and performance:
- High Precision Lithographic Mastering
Utilized to create intricate microfluidic structures with exceptional accuracy and two heights, ensuring the reliable performance of the IntelliSep platform.
- Precision Molding
Applied to produce complex, high-quality components consistently, crucial for the reproducibility and functionality of the diagnostic device.
- Advanced Bonding Techniques
Employed to assemble microfluidic devices with very high accuracy, achieving channel heights with a precision of ±200 nm, essential for the device's functionality and reliability.
- Quality Control (QC)
Implemented stringent QC measures throughout the manufacturing process to guarantee the highest standards of product quality and performance.
ADVANTAGES
The INTELLISEP system from Cytovale offers several key advantages:
Rapid Diagnosis: Provides quick identification of sepsis, allowing for timely intervention and treatment.
High Accuracy: Utilizes innovative cell biophysical properties to deliver precise and reliable results.
Ease of Use: Designed for straightforward integration into clinical workflows, minimizing the need for extensive training.
Improved Patient Outcomes: Enhances clinical decision-making, leading to better patient management and outcomes.
Cost-Effective: Helps contain healthcare costs by reducing unnecessary treatments and hospital stays through early and accurate diagnosis.
Versatile Application: Suitable for various clinical settings, including emergency departments, ICUs, and hospital wards.
Regulatory Approved: Meets stringent regulatory standards, ensuring safety and efficacy in clinical use.
These advantages make the Intellisep system a powerful tool in biomedical research and diagnostics.
STRATEC Competences
Involved Services
The development and manufacturing of the Cytovale platform involved key teams at STRATEC Consumables as follows:
Mastering
Realized the high-precision, two level master and the injection molding inserts derived from it.
Bonding & Automation
Implemented an automated solvent bonding processes to precisely achieve homogeneous channel heights.
